Following are notable people who were either born, raised, or have lived for a significant period of time in Saugus, Massachusetts:
| Name | Description |
|---|---|
| Ross Alameddine | Student killed during the Virginia Tech massacre. |
| Joseph Alexander Ames | Portrait artist. |
| Nathan Ames | Inverntor credited with patenting the first escalator in 1859. |
| Steven Angelo | Town administrator and politician. |
| Stephen Bachiler | An English clergyman who was an early proponent of the separation of church and state. |
| Belden Bly | Member of the Massachusetts House of Representatives from 1948 to 1979. |
| Paul H. Boucher | Town Manager of Saugus, Massachusetts (1967–1968) and Village Manager of Maywood, Illinois (1970–1970). |
| Tom Brunansky [1] | Former Major League Baseball right fielder. |
| Wayne Budd | Former U.S. Attorney for Massachusetts and United States Associate Attorney General. |
| Jared Carrabis | Red Sox Nation Governor of Massachusetts[2] and is the founder and writer for the Red Sox blog, SoxSpace.[1]; authored a book, One Fan's Story: If This Hat Could Talk, and is a columnist for the Saugus Advertiser. |
| Jonathan Cheever | Snowboarder |
| Don Cherry [3] | Former National Hockey League head coach and current Hockey Night in Canada analyst. |
| Michael Cresta | Scrabble player. Holds the world records for highest game score, highest combined score, and highest score on a single play. [4] |
| John Curry | Former president of Northeastern University. |
| Arthur F. DeFranzo | U.S. Army soldier and Medal of Honor recipient in World War II. |
| Gary Doak [5] | Former National Hockey League Defenceman. |
| Ed Fallon | Member of the Iowa House of Representatives from the 66th district (1993–2006), Candidate for Governor of Iowa (2002) and US House of Representatives (2006). |
| Mark Falzone | Member of the Massachusetts House of Representatives from the Ninth Essex District from 2001–2011. |
| Cornelius Conway Felton | Regent of the Smithsonian Institution, as well as president of Harvard University. |
| John B. Felton | Mayor of Oakland, California (1869-1871), namesake of Felton, California. |
| Samuel Morse Felton, Sr. | Railroad executive. |
| Fanny Fern | A popular columnist, humorist, novelist, and author of children's stories. |
| Vincent Ferrini | American writer and poet. |
| Ellen Fitzgerald | Miss Massachusetts 1993. |
| Gustavus Fox | Assistant Secretary of the Navy during the Civil War. |
| Edmund Freeman | One of the founders of Sandwich, Massachusetts and the Deputy Governor of Plymouth Colony under Governor William Bradford. |
| Bob Gaudet [6] | Head men's ice hockey coach at Dartmouth College. |
| John Geoghan | Priest who was a key figure in the Roman Catholic sex abuse cases. |
| Paul G. Hewitt | American physicist, former boxer, uranium prospector, author, and cartoonist. |
| Horace Hillis | Socialist Labor politician in the state of Massachusetts from 1936-1950. |
| Sagamore James | Sachem of the Saugus, Lynn and Marblehead areas. Son of Nanepashemet. |
| Phyllis Katsakiores | Member of the New Hampshire House of Representatives (1982–Present). |
| Rose Kaufman | Screenwriter The Wanderers and Henry & June. |
| Tim Kelly | American playwright. |
| John B. Kennedy | City Manager of Medford, Massachusetts (1957–1958) and Town Manager of Norwood, Massachusetts (1951–1957) and Saugus (1958–1960). Candidate for Treasurer and Receiver-General of Massachusetts in 1960. |
| Kyle Kucharski | Forward for the Gwinnett Gladiators. |
| Dave Lucey | Registrar of Motor Vehicles from 1972-1974. |
| Susan Lynch | First Lady of New Hampshire. |
| Doug Mackie | Offensive tackle who played for the New York Giants and Atlanta Falcons of the National Football League and the Tampa Bay Bandits and New Jersey Generals of the United States Football League. |
| William Moulton Marston | Psychologist, feminist theorist, and comic book writer who created Wonder Woman. |
| Darrell Martinie | National radio personality and official state astrologer for Massachusetts. |
| Bob Montgomery | Former Major League Baseball catcher who played for the Boston Red Sox from 1970 to 1979. |
| Deborah Moody | The only woman to found a colonial settlement in early North America. |
| Henry Newhall | An American businessman whose land holdings eventually formed the city of Saugus, California. |
| Eddie Palladino | Public address announcer for the Boston Celtics. |
| Lydia Pinkham | A patent medicine manufacturer and businesswoman. |
| Arlie Pond | Former Major League Pitcher for the Baltimore Orioles. |
| C. F. Nelson Pratt | American politician. |
| Johnny Rae | American jazz drummer and vibraphonist. |
| Eileen Rose | American singer-songwriter. |
| Verne E. Rupright | The current mayor of Wasilla, Alaska. |
| John P. Slattery[7] | Member of the Massachusetts House of Representatives from the 12th Essex District from 1995–2003. |
| Chris Serino [8] | Former head men's hockey coach at Merrimack College and head baseball coach at the University of New Hampshire. |
| Art Spinney | Guard who played 9 seasons with the Baltimore Colts. |
| Art Statuto | Center who played for the Los Angeles Rams of the National Football League and the Buffalo Bills of the All-America Football Conference. |
| Marion L. Starkey | Author of numerous books including The Devil in Massachusetts. |
| William Tudor | A wealthy lawyer and leading citizen of Boston. |
| Winnepurket | Sachem of Saugus, Massachusetts. Married to Weetamoo. |
| Sandra Whyte | Ice hockey player. Gold medal winner at the 1998 Winter Olympics. |
| Frederick Willis | Speaker of the Massachusetts House of Representatives from 1944-1948. |
| Donald Wong | Representative for the 9th Essex District of the Massachusetts House of Representatives and former Chairman of the Saugus Board of Selectmen. |
| Kevin Wortman | Former professional hockey player for the Calgary Flames. |